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Structural characterization of EasH (Aspergillus japonicus) – an oxidase involved in cycloclavine biosynthesis
- Jakubczyk, Dorota, Caputi, Lorenzo, Stevenson, Clare E. M., Lawson, David M., O'Connor, Sarah E.
- Chemical communications 2016 v.52 no.99 pp. 14306-14309
- Aspergillus japonicus, biosynthesis, chemical reactions, ergot alkaloids, fungi, oxidoreductases
- Aj_EasH is a non-heme iron- and α-keto-glutarate-dependent oxidase that is responsible for an unusual cyclopropyl ring formation in the biosynthesis of the fungal ergot alkaloid cycloclavine. The three dimensional structure of Aj_EasH (2.2 Å resolution) reported here provides insight into the mechanism of this unusual and complex reaction.