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Self-assembled lipoprotein based gold nanoparticles for detection and photothermal disaggregation of β-amyloid aggregates
- Martins, P. A. T., Alsaiari, S., Julfakyan, K., Nie, Z., Khashab, N. M.
- Chemical communications 2017 v.53 no.13 pp. 2102-2105
- amyloid, chemical reactions, curcumin, fluorescence, gold, lipoproteins, nanogold, nanoparticles
- We present a reconstituted lipoprotein-based nanoparticle platform comprising a curcumin fluorescent motif and an NIR responsive gold core. This multifunctional nanosystem is successfully used for aggregation-dependent fluorescence detection and photothermal disassembly of insoluble amyloid aggregates.