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A GSH-activatable ruthenium(ii)-azo photosensitizer for two-photon photodynamic therapy

Author:
ZengThese authors contribute equally to this work., Leli, Kuang, Shi, Li, Guanying, Jin, Chengzhi, Ji, Liangnian, Chao, Hui
Source:
Chemical communications 2017 v.53 no.12 pp. 1977-1980
ISSN:
1364-548X
Subject:
antineoplastic agents, chemical reactions, glutathione, neoplasms, photochemotherapy, photosensitizing agents, phototoxicity, ruthenium
Abstract:
A glutathione (GSH)-activatable ruthenium(ii)-azo photosensitizer was prepared. The complex had low toxicity towards cells under dark conditions. It exhibited excellent phototoxicity under two-photon excitation (810 nm) and thus was developed as a two-photon photodynamic anticancer agent for cancer therapy.
Agid:
6390791