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Single-molecule imaging of telomerase activity via linear plasmon rulers
- Qian, Guang-Sheng, Zhang, Ting-Ting, Zhao, Wei, Xu, Jing-Juan, Chen, Hong-Yuan
- Chemical communications 2017 v.53 no.34 pp. 4710-4713
- chemical reactions, enzyme activity, image analysis, monitoring, nanoparticles, silver, telomerase
- Plasmon rulers (PRs) exploit the potential of plasmon coupling between individual pairs of noble metal nanoparticles in biological processes, especially single-molecule detection. Herein, for the first time, we report a strategy based on Ag PRs for in situ monitoring of the extension process of telomerase primer (TSP) activated by a single telomerase.