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A general diastereoselective synthesis of highly functionalized ferrocenyl ambiphiles enabled on a large scale by electrochemical purification

Author:
Lerayer, Emmanuel, Renaut, Patrice, Roger, Julien, Pirio, Nadine, Cattey, Hélène, Devillers, Charles H., Lucas, Dominique, Hierso, Jean-Cyrille
Source:
Chemical communications 2017 v.53 no.44 pp. 6017-6020
ISSN:
1364-548X
Subject:
antagonists, chemical compounds, diastereoselective synthesis, diastereoselectivity, electrochemistry, moieties, optical isomerism
Abstract:
A general synthesis of highly functionalized ferrocenes, which include (P,B)- and (N,B)-ambiphiles, has been developed at a multigram scale. Diastereoselective stepwise modification of di-tert-butylated ferrocenes included the unprecedented separation of electroactive species. Bulky alkyl groups on ferrocenes ensure planar chirality of ambiphiles and enforce closer proximity of antagonist Lewis functions.
Agid:
6391515