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Cp*Coᴵᴵᴵ-catalyzed directed C–H trifluoromethylthiolation of 2-phenylpyridines and 6-arylpurines
- Yoshida, Misaki, Kawai, Kentaro, Tanaka, Ryo, Yoshino, Tatsuhiko, Matsunaga, Shigeki
- Chemical communications 2017 v.53 no.44 pp. 5974-5977
- Lewis acids, catalysts, chemical reactions
- Cp*Coᴵᴵᴵ-catalyzed directed C–H trifluoromethylthiolation using N-trifluoromethylthiodibenzenesulfonimide as an electrophilic SCF₃ source is described. 6-Arylpurines, an important structural motif in medicinal chemistry, and 2-phenylpyridines selectively afforded mono-trifluoromethylthiolated products in moderate to good yields using an inexpensive first-row transition metal catalyst.