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Evolutionary dynamics of carbapenem-resistant Acinetobacter baumannii circulating in Chilean hospitals
- Opazo-Capurro, Andrés, San Martín, Iván, Quezada-Aguiluz, Mario, Morales-León, Felipe, Domínguez-Yévenes, Mariana, Lima, Celia A., Esposito, Fernanda, Cerdeira, Louise, Bello-Toledo, Helia, Lincopan, Nilton, González-Rocha, Gerardo
- Infection, genetics, and evolution 2019 v.73 pp. 93-97
- Acinetobacter baumannii, beta-lactamase, cross infection, epidemiology, hospitals, Chile
- We analyze the evolutionary dynamics of ninety carbapenem-resistant Acinetobacter baumannii (CRAB) isolates collected between 1990 and 2015 in Chile. CRAB were identified at first in an isolate collected in 2005, which harbored the ISAba1-blaOXA-69 arrangement. Later, OXA-58- and OXA-23-producing A. baumannii strains emerged in 2007 and 2009, respectively. This phenomenon was associated with variations in the epidemiology of OXA-type carbapenemases, linked to nosocomial lineages belonging to ST109, ST162, ST15 (CC15) and ST318 (CC15).