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One new sesquiterpene and one new iridoid derivative from Valeriana amurensis

Author:
Xie, Yang-Guo, Zhao, Xin-Cai, ul Hassan, Syed Shams, Zhen, Xiao-Yong, Muhammad, Ishaq, Yan, Shi-kai, Yuan, Xing, Li, Hui-liang, Jin, Hui-zi
Source:
Phytochemistry letters 2019 v.32 pp. 6-9
ISSN:
1874-3900
Subject:
Valeriana, X-ray diffraction, anti-inflammatory activity, inhibitory concentration 50, irradiation, macrophages, nitric oxide, sesquiterpenoids, spectral analysis, stereochemistry
Abstract:
One new sesquiterpene 1S, 3S, 4S, 7S 3,4-dihydroxy-bisabolol (1), one new iridoid amurensin A (2) and 10 known compounds were isolated from the whole plants of Valeriana amurensis. Their structures were established on the basis of extensive spectroscopic analysis and the absolute stereochemistry of compound 1 was assigned by X-ray diffraction analysis with Cu-Kα irradiation. All of compounds were evaluated for their inhibitory effects on NO production in LPS-induced RAW264.7 macrophages. Compound 12 displayed significant anti-inflammatory activity with IC50 value of 1.97 μM.
Agid:
6394914