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Synthesis of symmetrical pyridines by iron-catalyzed cyclization of ketoxime acetates and aldehydes
- YiThese authors contributed equally., YuKun, Zhao, Mi-Na, Ren, Zhi-Hui, Wang, Yao-Yu, Guan, Zheng-Hui
- Green chemistry 2017 v.19 no.4 pp. 1023-1027
- acetates, aldehydes, catalysts, ferric chloride, green chemistry, moieties, pyridines
- A novel and facile iron-catalyzed cyclization of ketoxime acetates and aldehydes for the green synthesis of substituted pyridines has been developed. In the presence of a FeCl₃ catalyst, this reaction exhibited a good functional group tolerance to produce 2,4,6-triarylsubstituted symmetrical pyridines in high yields in the absence of any additive. A gram-scale reaction sequence was performed to demonstrate the scaled-up applicability of this synthetic method.