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Copper-catalyzed aerobic benzylic sp³ C–H oxidation mediated synthesis of 2,4,5-trisubstituted imidazoles via a domino multi-component reaction
- Jayram, Janeeka, Jeena, Vineet
- Green chemistry 2017 v.19 no.24 pp. 5841-5845
- copper, green chemistry, imidazoles, ketones, oxidation, oxygen
- An efficient and practical aerobic benzylic sp³ C–H oxidation as a key step towards the domino multi-component synthesis of 2,4,5-trisubstituted imidazoles has been reported. This green methodology employs an inexpensive catalytic copper/oxygen system and proceeds under mild reaction conditions. A variety of substituted imidazoles are prepared in moderate to excellent yields from α-methylene ketones using this innovative methodology.