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DNA-mediated reversible capture and release of circulating tumor cells with a multivalent dual-specific aptamer coating network

Author:
Lin, Yuhong, Jiang, Lili, Huang, Yuqing, Yang, Yuling, He, Yu, Lu, Chunhua, Yang, Huanghao
Source:
Chemical communications 2019 v.55 no.37 pp. 5387-5390
ISSN:
1364-548X
Subject:
binding capacity, binding sites, chemical compounds, chemical reactions, neoplasm cells, oligonucleotides
Abstract:
DNA-triggered reversible isolation and recovery of circulating tumor cells (CTCs) is presented based on a multivalent dual-specific aptamer-tethered rolling circle amplification (MA-RCA) network. The multivalent binding sites endow the MA-RCA network with a strong binding ability towards CTCs, and the repeated cell capture/release processes are also actualized in a noninvasive manner.
Agid:
6400229