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Synthesis of 4-arylamino-3-(trifluoromethyl)pyridazines and pyridazino[3,4-b]quinoxalines (as by-products) from 3-aroylmethyl-2-(trifluoromethyl)quinoxalines and hydrazine hydrate
- Sosnovskikh, Vyacheslav Y., Safrygin, Alexander V., Irgashev, Roman A., Ezhikova, Marina A., Kodess, Mikhail I.
- RSC advances 2016 v.6 no.36 pp. 30056-30069
- acetic acid, butanol, byproducts, pyridazines, quinoxalines, reaction mechanisms
- A number of 4-arylamino-3-(trifluoromethyl)pyridazines were obtained in good yields via the novel reaction of 3-aroylmethyl-2-(trifluoromethyl)quinoxalines with an excess of hydrazine hydrate in refluxing n-butanol with or without acetic acid. This reaction is accompanied by the formation of side-products with the pyridazino[3,4-b]quinoxaline skeleton. The possible reaction mechanism was discussed.