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An aggregation-induced emission-based pH-sensitive fluorescent probe for intracellular acidity sensing

Author:
Lin, Na, Chen, Xiaohong, Yan, Shuanghong, Wang, Han, Lu, Zhixiang, Xia, Xin, Liang, Mengyu, Wu, Yun-Long, Zheng, Liyan, Cao, Qiue, Ding, Zhongtao
Source:
RSC advances 2016 v.6 no.30 pp. 25416-25419
ISSN:
2046-2069
Subject:
acidity, deprotonation, fluorescence, fluorescent dyes, lysosomes, mice, neoplasm cells, neoplasms
Abstract:
A dual-emission pH-sensitive fluorescent probe was developed, which displays green fluorescence in alkaline after deprotonation, while orange emission in acid at aggregated state. This novel probe allows the specific light-on in acidic lysosomes of cancer cells and tumors in nude mice, which indicates its potential application in cancer diagnosis.
Agid:
6403941