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Co(acac)₂/O₂-catalyzed oxidative isocyanide insertion with 2-vinylanilines: efficient synthesis of 2-aminoquinolines
- Xu, Pei, Zhu, Tong-Hao, Wei, Tian-Qi, Wang, Shun-Yi, Ji, Shun-Jun
- RSC advances 2016 v.6 no.39 pp. 32467-32470
- catalysts, cobalt, oxidants, oxygen, toxicity
- A series of 2-aminoquinolines were afforded by Co(acac)₂ catalyzed isocyanide insertion with 2-vinylanilines under an O₂ atmosphere. This reaction not only uses low toxicity Co(acac)₂ as the catalyst and oxygen as the oxidant, but also allows the construction of new C(sp²)–C(sp²) and C(sp²)–N bonds in a single-step.