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Red-emitting, EtTP-5-based organic nanoprobes for two-photon imaging in 3D multicellular biological models
- Pinkerton, Nathalie M., Frongia, Céline, Lobjois, Valérie, Wilson, Brian K., Bruzek, Matthew J., Prud'homme, Robert K., Anthony, John, Bolze, Frédéric, Chassaing, Stefan
- RSC advances 2016 v.6 no.70 pp. 65770-65774
- biological models, fluorescent dyes, image analysis, nanoparticles
- Biocompatible and biostable EtTP-5-loaded organic core–shell nanoparticles have been successfully evaluated for their potential as red-emitting fluorescent nanoprobes for two-photon imaging. Readily formed by Flash NanoPrecipitation, EtTP-5-based nanoprobes proved to penetrate well into multicellular spheroids and were easily imaged through several cell layers within these complex, 3D tissue models.