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Fabrication of a novel chitosan scaffold with asymmetric structure for guided tissue regeneration
- Yang, Ling, Lu, Wentao, Pang, Yichuan, Huang, Xiaofei, Wang, Zhengke, Qin, An, Hu, Qiaoling
- RSC advances 2016 v.6 no.75 pp. 71567-71573
- biocompatibility, chitosan, histology, mechanical properties, micro-computed tomography, microstructure, models, osteoblasts, rats, skull, therapeutics, tissue repair
- A novel chitosan (CS)-based asymmetric scaffold composed of a dense layer and a loose layer was fabricated via the self-deposition approach. The micro-structure and mechanical properties were verified to satisfy the criteria for the guided tissue regeneration (GTR) membrane. The in vitro biocompatibility of the scaffold was verified by the CCK-8 assays of MC3T3 osteoblastic cells. The rat skull defect model was applied to estimate the in vivo bone regeneration performance. The micro-CT and histological results manifested its outstanding bone regenerative ability and superior degradability over the Bio-gide® membrane. Considering the relative low expense and simple fabrication process, the prepared asymmetric CS scaffold is a prospective candidate for GTR therapy.