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Modulating the DNA strand-displacement kinetics with the one-sided remote toehold design for differentiation of single-base mismatched DNA
- Li, Chenxi, Li, Yixin, Chen, Yang, Lin, Ruoyun, Li, Tian, Liu, Feng, Li, Na
- RSC advances 2016 v.6 no.78 pp. 74913-74916
- DNA, base pair mismatch, reaction kinetics
- A one-sided remote toehold design was proposed to provide the fine control over strand-displacement reaction kinetics with simplicity and versatility. The significantly improved single-base mismatch differentiating ability of reactions was achieved for strand-displacement reaction systems with the rate-saturated toehold length.