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One-pot transition-metal-free cascade synthesis of thieno[2,3-c]coumarins from chromones
- Yang, Yuhong, Qi, Xueyu, Liu, Ruiling, He, Qian, Yang, Chunhao
- RSC advances 2016 v.6 no.106 pp. 103895-103898
- coumarins, cyclization reactions, moieties, synthesis
- A one-pot transition-metal-free, base-mediated synthesis of a novel series of functionalized thieno[2,3-c]coumarins via a cascade reaction from chromones has been developed. This cascade reaction involves a Michael addition–Knoevenagel condensation–intramolecular cyclization. This transformation proceeds under mild conditions and gives various thieno[2,3-c]coumarins in good-to-excellent yields. The methodology is tolerant of a wide range of functional groups and applicable to library synthesis.