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Few molecule SERS detection using nanolens based plasmonic nanostructure: application to point mutation detection
- Das, Gobind, Alrasheed, Salma, Coluccio, Maria Laura, Gentile, Francesco, Nicastri, Annalisa, Candeloro, Patrizio, Cuda, Giovanni, Perozziello, Gerardo, Di Fabrizio, Enzo
- RSC advances 2016 v.6 no.109 pp. 107916-107923
- disease detection, nanomaterials, point mutation, rhodamines, simulation models, synthetic peptides
- Advancements in nanotechnology fabrication techniques allow the possibility to design and fabricate a device with a minimum gap (<10 nm) between the composing nanostructures in order to obtain better control over the creation and spatial definition of plasmonic hot-spots. The present study is intended to show the fabrication of nanolens and their application to single/few molecules detection. Theoretical simulations were performed on different designs of real structures, including comparison of rough and smooth surfaces. Various molecules (rhodamine 6G, benzenethiol and BRCA1/BRCT peptides) were examined in this regard. Single molecule detection was possible for synthetic peptides, with a possible application in early detection of diseases.