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A nano-organo catalyzed route towards the efficient synthesis of benzo[b]pyran derivatives under ultrasonic irradiation

Nongrum, Ridaphun, Nongthombam, Geetmani Singh, Kharkongor, Mattilang, Star Rani, Jims World, Rahman, Noimur, Kathing, Chingrishon, Myrboh, Bekington, Nongkhlaw, Rishanlang
RSC advances 2016 v.6 no.110 pp. 108384-108392
Fourier transform infrared spectroscopy, X-ray diffraction, adverse effects, catalysts, catalytic activity, chlorpyrifos, energy, energy-dispersive X-ray analysis, gills, magnetism, nanomaterials, pyrans, silica, solvents, synthesis, tadpoles, thiamin, transmission electron microscopy, ultrasonic treatment, ultrasonics
An efficient, one-pot synthesis of benzo[b]pyrans catalyzed by vitamin B₁ functionalized Fe₂O₃@SiO₂ NPs under ultrasonic conditions is reported herein. The nano-organocatalyst was synthesized and characterized by FT-IR, TEM, EDS, powder XRD, etc. Several benzo[b]pyran derivatives were prepared with satisfactory yields and the nanocatalyst was magnetically retrieved and recycled. The salient features of this protocol include convenient work-up procedure, mild reaction conditions, easy catalyst recovery, shorter reaction time and use of green solvents. Ultrasound energy has been meticulously exploited for the synthesis of a nano-organocatalyst as well as for the preparation of several benzo[b]pyran derivatives. The biological activity of the synthesized benzo[b]pyrans were investigated and one of the derivatives was found to demonstrate profound activity in suppressing the side-effects of chlorpyrifos, an insecticide on the morphology of the external gills of the Duttaphrynus melanostictus tadpoles.