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A novel rosamine-based fluorescent probe for bisulfite in aqueous solution
- Zhang, Di, Wenya, Liu, Chen, Keke, Cheng, Junye, Zhao, Yufen, Ye, Yong
- RSC advances 2016 v.6 no.106 pp. 103905-103909
- aqueous solutions, bisulfites, detection limit, fluorescence, fluorescent dyes, hydrogen, image analysis, moieties
- A new rosamine-based fluorescent probe (RosCHO) for bisulfite was obtained by one pot reaction of p-phthalaldehyde and 3-(diethylamino)phenol, which showed excellent selectivity, high sensitivity and a rapid response toward bisulfite in aqueous solution. Upon the addition of HSO₃⁻, the aldehyde moiety in probe RosCHO formed a hydrogen sulfite-dependent adduct product, leading to fluorescence enhancement due to the different ICT process. The detection limit for bisulfite was as low as 7 × 10⁻⁸ M, and fluorescence imaging of bisulfite in MCF-7 cells demonstrated its value to practical application in biological systems.