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Facile single-step bioconjugation of the antifungal agent caspofungin onto material surfaces via an epoxide plasma polymer interlayer

Author:
Michl, Thomas D., Giles, Carla, Cross, Alasdair T., Griesser, Hans J., Coad, Bryan R.
Source:
RSC advances 2017 v.7 no.44 pp. 27678-27681
ISSN:
2046-2069
Subject:
Candida albicans, Candida glabrata, adsorption, albumins, biofilm, caspofungin, chemical bonding, coatings, detergents, fungi, pathogens, polymers, washing
Abstract:
We report a facile, one-step, aqueous surface bioconjugation approach for producing an antifungal surface coating that prevents the formation of fungal biofilms. By direct reaction between surface epoxide groups and amine groups on caspofungin, it avoids the use of secondary chemicals. The coating withstands washing with detergent and reduces the growth of the fungal pathogens Candida albicans by log 6 and Candida glabrata by log 3. Importantly, we show that surface adsorption of albumin does not inhibit the activity of this antifungal coating.
Agid:
6416513