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Enabling the facile conversion of acyl hydrazides into N-acyl carbamates via metal-free ionic-based rupture of the N–N linkage

Author:
Shamsabadi, André, Ren, Jack, Chudasama, Vijay
Source:
RSC advances 2017 v.7 no.44 pp. 27608-27611
ISSN:
2046-2069
Subject:
carbamates, hydrazides, moieties
Abstract:
Herein we report the one-pot transformation of readily synthesised/easily accessed acyl hydrazides into N-acyl carbamates via an alkylation-elimination reaction sequence. A range of N-acyl carbamates are prepared in consistent yields, including those featuring protecting groups and having alkyl & aryl N-acyl functionality. The reaction conditions also tolerate a wide variety of sensitive functional groups.
Agid:
6416564