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An antimalarial drug, tafenoquine, as a fluorescent receptor for ratiometric detection of hypochlorite

Author:
Das, Avijit Kumar, Hayashi, Naoto, Shiraishi, Yasuhiro, Hirai, Takayuki
Source:
RSC advances 2017 v.7 no.48 pp. 30453-30458
ISSN:
2046-2069
Subject:
analytical kits, antimalarials, fluorescence, fluorometry, image analysis, moieties, pH
Abstract:
Tafenoquine (TQ), a fluorescent antimalarial drug, was used as a receptor for the fluorometric detection of hypochlorite (OCl⁻). TQ itself exhibits a strong fluorescence at 476 nm, but OCl⁻-selective cyclization of its pentan-1,4-diamine moiety creates a blue-shifted fluorescence at 361 nm. This ratiometric response facilitates rapid, selective, and sensitive detection of OCl⁻ in aqueous media with physiological pH. This response is also applicable to a simple test kit analysis and allows fluorometric OCl⁻ imaging in living cells.
Agid:
6419952