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An electrochemical biosensor for detection of the sepsis-related biomarker procalcitonin

Author:
Lim, Jong Min, Ryu, Myung Yi, Kim, Ji Hong, Cho, Chae Hwan, Park, Tae Jung, Park, Jong Pil
Source:
RSC advances 2017 v.7 no.58 pp. 36562-36565
ISSN:
2046-2069
Subject:
biomarkers, biosensors, electrochemistry, sepsis (infection), synthetic peptides
Abstract:
An electrochemical peptide sensor employing a sensitive synthetic peptide was designed for the diagnosis of sepsis. A series of synthetic peptides were chemically synthesized, and the binding events and performance of the sensor were monitored by CV and EIS. PCT BP3, selected as a potential high-affinity peptide, was found to have a Kd value of 0.39 ± 0.11 nM for procalcitonin.
Agid:
6420598