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Heat shock protein-peptide interaction as the basis for a new generation of vaccines against cancers and infectious diseases
- Srivastava, Pramod K
- Journal of biosciences 1998 v.23 no.4 pp. 527-531
- T-lymphocytes, cell-mediated immunity, epitopes, heat shock proteins, heat stress, immunization, infectious diseases, neoplasms, pathogens, peptides, vaccines
- Heat shock proteins (HSPs) are associatedin vivo with the entire repertoire of peptides (antigenic and otherwise) generated within that cell. Immunization with such HSP-peptide complexes is unusually efficient in eliciting cellular immune responses against the antigenic peptides associated with the HSPs. This broad and general principle is the basis for a new generation of vaccines against cancers and infectious diseases and circumvents the need for identification of the T cell epitopes for any given cancer or infectious agent.