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Frequency and potential application of HLA antibodies from pregnant women in Mumbai
- Shankarkumar, U., Gupte, S. C., Gupte, S. S., Pednkar, S. V., Ghosh, K., Mohanty, D.
- Journal of biosciences 1998 v.23 no.5 pp. 601-604
- antibodies, cost effectiveness, females, gene frequency, hospitals, pregnant women, screening, India
- Antenatal sera from 1334 pregnant women attending the Nowrojee B J Wadia Maternity Hospital and KEM Hospital in Parel, Mumbai were collected and screened for anti HLA A and B antibodies to produce an indigenous HLA tissue typing tray. One hundred and sixty three sera (12.2%) were found positive for HLA antibodies. Nonetheless, the percentage of positive sera were almost the same in women of different parity. Moreover, the incidence of anti-HLA antibodies was correlated with the allelic frequencies in the Maharastrian population. Thus in India, collection and screening of sera from pregnant females is a simple and cost-effective method of acquiring polyclonal sera for routine use in tissue typing.