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Aptamer-functionalized DNA microgels: a strategy towards selective anticancer therapeutic systems

Author:
Wang, Yitong, Yan, Miaomiao, Xu, Lu, Zhao, Wenrong, Wang, Xiaolin, Dong, Shuli, Hao, Jingcheng
Source:
Journal of materials chemistry B 2016 v.4 no.32 pp. 5446-5454
ISSN:
2050-7518
Subject:
DNA, acrylamides, antineoplastic agents, biocompatibility, composite polymers, crosslinking, drug carriers, free radicals, microgels, moieties, neoplasm cells, neoplasms, oligonucleotides, polymerization
Abstract:
DNA microgels of oligonucleotides and polymers were constructed via a combination of DNA complementarity and photo-initiated free radical polymerization. The DNA microgels did not feature the conventional core–shell structure but were instead based on the copolymers of N-isopropylacrylamide and acrylamide and DNA crosslinks. By incorporating the aptamer-functionalized moieties, the AptMG–Dox system was demonstrated to possess excellent biocompatibility and highly selective killing efficacy for target cancer cells via stimuli-responsiveness, which could provide immense potential as an intelligent drug delivery carrier for targeted cancer therapy.
Agid:
6424415