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Overcoming multidrug resistance by a combination of chemotherapy and photothermal therapy mediated by carbon nanohorns

Author:
Wang, Junling, Wang, Ran, Zhang, Fangrong, Yin, Yajun, Mei, Leixia, Song, Fengjuan, Tao, Mingtao, Yue, Wanqing, Zhong, Wenying
Source:
Journal of materials chemistry B 2016 v.4 no.36 pp. 6043-6051
ISSN:
2050-7518
Subject:
P-glycoproteins, carbon, drug delivery systems, drug therapy, etoposide, irradiation, ligands, monoclonal antibodies, multiple drug resistance, near infrared radiation, neoplasms, oxidation, photothermotherapy, polyethylene glycol, synergism
Abstract:
Multidrug resistance (MDR) is a major obstacle to cancer chemotherapy due to the overexpression of P-glycoprotein (P-gp). Herein, etoposide (ETO) was loaded onto oxidized carbon nanohorns (oxCNHs), which were modified by polyethylene glycol (PEG) and further functionalized with the targeting ligand P-gp monoclonal antibody (PA) in an attempt to overcome MDR. The obtained drug delivery system (ETO@oxCNHs/PEG-PA) showed high drug loading efficiency, enhanced drug release under laser irradiation, improved cellular uptake and increased therapeutic effect both in vitro and in vivo. In addition, NIR laser irradiation had a synergistic effect on overcoming MDR. The MDR-overcoming mechanism could be the efficient cellular uptake, enhanced drug release and reduced drug efflux by P-gp. These results demonstrated that ETO@oxCNHs/PEG-PA could be a promising drug delivery system for cancer MDR reversion.
Agid:
6424466