Jump to Main Content
Preparation and characterisation of an innovative injectable calcium sulphate based bone cement for vertebroplasty application
- Dadkhah, Mehran, Pontiroli, Lucia, Fiorilli, Sonia, Manca, Antonio, Tallia, Francesca, Tcacencu, Ion, Vitale-Brovarone, Chiara
- Journal of materials chemistry B 2016 v.5 no.1 pp. 102-115
- bioactive properties, body fluids, bone formation, calcium sulfate, cement, compression strength, crystals, hydroxyapatite, indirect contact, mechanical properties, mixing, polymethylmethacrylate, porous media, soaking, spray drying, Sweden
- In this study, an innovative injectable and bioresorbable composite cement (Spine-Ghost) has been developed by combining a radiopaque glass-ceramic powder (SCNZgc) and spray-dried mesoporous bioactive particles (W-SC) into type III alpha calcium sulphate hemihydrate (α-CSH) (composition α-CSH/SCNZgc/W-SC, 70/20/10 wt%). The Spine-Ghost cement and pure α-CSH (as a reference) were characterised in terms of physical and mechanical properties and compared to a commercial reference (Cerament® – Bonesupport AB, Sweden). The Spine-Ghost cement had a setting time comparable with Cerament® showing a good injectability in the range of 8–20 minutes after the end of mixing. In addition, the Spine-Ghost cement showed a good radiopacity when compared with standard PMMA (BonOs Inject, aap Biomaterials GmbH Germany) and higher compressive strength when compared to healthy cancellous bone. The bioactivity of both Spine-Ghost and Cerament® was evaluated through in vitro soaking in simulated body fluid (SBF). Spine-Ghost samples were highly bioactive, inducing the precipitation of hydroxyapatite crystals in the first week of soaking in vitro. It was also found that the degradation kinetics of the Spine-Ghost cement were faster than those of pure α-CSH and comparable to those of Cerament® after approximately 1 month of soaking in SBF. Moreover, the Spine-Ghost cement was cytocompatible in indirect-contact culture in vitro. Overall results indicate that the Spine-Ghost cement might be a very good candidate for vertebroplasty application and could enhance new bone formation in vivo.