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A fast-response two-photon fluorescent probe for the detection of Cys over GSH/Hcy with a large turn-on signal and its application in living tissues

Author:
Wang, Jian-Yong, Liu, Zhan-Rong, Ren, Mingguang, Kong, Xiuqi, Lin, Weiying
Source:
Journal of materials chemistry B 2016 v.5 no.1 pp. 134-138
ISSN:
2050-7518
Subject:
cysteine, cytotoxicity, edema, fluorescent dyes, image analysis, liver, skin lesions, tissues
Abstract:
Cysteine (Cys), a small-molecule aminothiol, plays important roles in various physiological processes in connection with various diseases, such as skin lesions, edema, hair depigmentation and liver damage. We developed a novel two-photon fluorescent probe for sensing Cys in presence of GSH and Hcy in vivo. The two-photon fluorescent probe exhibited favorable properties, including fast response (about 20 min), good selectivity, and low cytotoxicity. Furthermore, it was successfully applied for imaging Cys in living cells and tissues.
Agid:
6424714