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Accumulation of unusual sterile transcripts of TCRβ in mouse hybridoma, murine tumour and non-human primate marmoset tumour

Author:
Bhattacharya, P.
Source:
Journal of biosciences 1999 v.24 no.4 pp. 441-444
ISSN:
0250-5991
Subject:
B-lymphocytes, T-lymphocytes, antibodies, complementary DNA, genes, germ cells, humans, hybridomas, immunoglobulin class switching, immunoglobulins, loci, messenger RNA, mice, neoplasms, nucleic acid hybridization
Abstract:
Accumulation of immunoglobulin Ig RNA (from several loci viz., CH, Cα, Jₖ-Cₖ and Sμ during Igμ isotype switching) in B cells and T cell receptor (TCR) RNAs (α, β andγ) in T cells of unusual sizes emanating from germline and rearranged genes were reported to accumulate in human and mouse (and murine too). The precise mechanism and function of these sterile RNA species are yet to be delineated. Similar accumulation of RNA species of unusual sizes were identified with DNA-RNA hybridization and isolation of cDNA employing with DNA and antibody probes in mouse hybridoma, murine tumour, non-human primate marmoset tumour and human leukemic cells.
Agid:
6428293