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miR-613 inhibits Warburg effect in gastric cancer by targeting PFKFB2

Author:
Liu, Haipeng, Chen, Kang, Wang, Li, Zeng, Xiangting, Huang, Zeping, Li, Mei, Dong, Peng, Chen, Xiao
Source:
Biochemical and biophysical research communications 2019 v.515 no.1 pp. 37-43
ISSN:
0006-291X
Subject:
3' untranslated regions, carcinogenesis, cell growth, cell proliferation, glycolysis, lymph nodes, patients, stomach neoplasms, tissues
Abstract:
miR-613 has been demonstrated to play critical roles in tumorigenesis and progression of a various type of cancers. However, its role and expression significance remain unclear in gastric cancer (GC). We detected the expression of miR-613 in 176 paired GC tissues and adjacent normal tissues, and found that miR-613 was significantly downregulated in GC tissues and its downregulation was correlated with T stage, lymph node invasion and advanced AJCC stages. Moreover, miR-613 expression could be an independent prognostic factor of GC. Biological function analysis indicated that miR-613 inhibited cell proliferation and invasion. Further analysis suggested that miR-613 inhibited Warburg effect of GC cells. Mechanically, we identified that miR-613 could directly bind to the 3′UTR of PFKFB2, thereby suppressing the expression of PFKFB2, which in turn, regulating glycolysis metabolism and cell growth. In conclusion, miR-613 served as a tumor suppressor by targeting PFKFB2, indicating that detecting miR-613 and modulation of miR-613 expression could be potential marker and clinical approach in GC patients.
Agid:
6428558