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miR-613 inhibits Warburg effect in gastric cancer by targeting PFKFB2

Liu, Haipeng, Chen, Kang, Wang, Li, Zeng, Xiangting, Huang, Zeping, Li, Mei, Dong, Peng, Chen, Xiao
Biochemical and biophysical research communications 2019 v.515 no.1 pp. 37-43
3' untranslated regions, carcinogenesis, cell growth, cell proliferation, glycolysis, lymph nodes, patients, stomach neoplasms, tissues
miR-613 has been demonstrated to play critical roles in tumorigenesis and progression of a various type of cancers. However, its role and expression significance remain unclear in gastric cancer (GC). We detected the expression of miR-613 in 176 paired GC tissues and adjacent normal tissues, and found that miR-613 was significantly downregulated in GC tissues and its downregulation was correlated with T stage, lymph node invasion and advanced AJCC stages. Moreover, miR-613 expression could be an independent prognostic factor of GC. Biological function analysis indicated that miR-613 inhibited cell proliferation and invasion. Further analysis suggested that miR-613 inhibited Warburg effect of GC cells. Mechanically, we identified that miR-613 could directly bind to the 3′UTR of PFKFB2, thereby suppressing the expression of PFKFB2, which in turn, regulating glycolysis metabolism and cell growth. In conclusion, miR-613 served as a tumor suppressor by targeting PFKFB2, indicating that detecting miR-613 and modulation of miR-613 expression could be potential marker and clinical approach in GC patients.