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Assessing measles vaccine failure in Tianjin, China

Masters, Nina B., Wagner, Abram L., Ding, Yaxing, Zhang, Ying, Boulton, Matthew L.
Vaccine 2019 v.37 no.25 pp. 3251-3254
case-control studies, children, data collection, disease surveillance, measles, notifiable disease, urban areas, vaccination, vaccines, China
Despite increasing global measles vaccination coverage, progress toward measles elimination has slowed in recent years. In China, children receive a measles-containing vaccine (MCV) at 8 months, 18–24 months, and some urban areas offer a third dose at age 4–6 years. However, substantial measles cases in Tianjin, China, occur among individuals who have received multiple MCV doses. This study describes the vaccination history of measles cases 8 months – 19 years old. Data came from measles cases in Tianjin’s reportable disease surveillance system (2009–2013), and from a case control study (2011–2015). Twenty-nine percent of those in the surveillance dataset and 54.4% of those in the case series received at least one dose of MCV. The minimum and median time-to-diagnosis since vaccination revealed an increase in time since vaccination for incremental doses. Considerable measles cases in Tianjin occur in vaccinated children, and further research is needed to understand the reasons for vaccine failure.