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Vaccine-derived varicella zoster infection in a kidney transplant recipient after zoster vaccine live administration

Author:
Ortiz-Brizuela, Edgar, Leal-Vega, Francisco, Cuellar-Rodríguez, Jennifer, Bobadilla-del-Valle, Miriam, Ponce-de-León, Alfredo
Source:
Vaccine 2019 v.37 no.27 pp. 3576-3579
ISSN:
0264-410X
Subject:
case studies, intravenous injection, kidney transplant, live vaccines, open reading frames, patients, polymerase chain reaction, sequence analysis
Abstract:
A 49-year-old kidney transplant recipient, presented with a skin rash, and interstitial infiltrates three weeks after receiving a live attenuated varicella-zoster vaccine. Varicella-zoster Oka-vaccine strain was detected in plasma by polymerase chain reaction and sequencing analysis targeting open reading frame 62 (ORF 62). She was treated successfully with intravenous acyclovir. Our case report supports the current contraindication of live attenuated varicella-zoster vaccine in the solid-organ transplant recipients. Recombinant subunit varicella-zoster vaccine may be the vaccine of choice in these patients; nevertheless, further information is required to establish its safety, efficacy, and optimal timing.
Agid:
6429610