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Effect of bilberry extract (Vaccinium myrtillus L.) on drug-metabolizing enzymes in rats
- Prokop, Jiří, Lněničková, Kateřina, Cibiček, Norbert, Kosina, Pavel, Tománková, Veronika, Jourová, Lenka, Láníčková, Tereza, Skálová, Lenka, Szotáková, Barbora, Anzenbacher, Pavel, Zapletalová, Iveta, Rácová, Zuzana, Anzenbacherová, Eva, Ulrichová, Jitka
- Food and chemical toxicology 2019 v.129 pp. 382-390
- Vaccinium myrtillus, anthocyanins, antioxidants, bilberries, cytochrome P-450, dietary supplements, drinking water, drugs, enzyme activity, enzymes, fruit extracts, fruits, gene expression, health promotion, health status, hematologic tests, in vivo studies, liver, messenger RNA, metabolism, rats, risk, secondary metabolites, toxicology
- Vaccinium myrtillus L. (bilberry) fruit is a blue-colored berry with a high content of anthocyanins. These bioactive secondary metabolites are considered to play a major role in the health-promoting properties of bilberries. Our in vivo study was designed to assess the possible influence of bilberry extract on drug-metabolizing enzymes (DMEs). Rats were exposed to bilberry extract in drinking water at two concentrations (0.15 and 1.5 g/L). Selected DMEs were determined (mRNA expression and enzymatic activity) after 29 and 58 days in rat liver. In addition, a panel of antioxidant, physiological, biochemical and hematological parameters was studied; these parameters did not demonstrate any impact of bilberry extract on the health status of rats. A significant increase in activity was observed in cytochrome P450 (CYP) 2C11 (131% of control) and CYP2E1 (122% of control) after a 29-day administration, while the consumption of a higher concentration for a longer time led to a mild activity decrease. Slight changes were observed in some other DMEs, but they remained insignificant from a physiological perspective. According to our results, we conclude that the consumption of bilberries as a food supplement should not pose a risk of interacting with co-administered drugs based on their metabolism.