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Development and characterization of dual sensitive poly(N,N-diethyl acrylamide) grafted alginate microparticles

Işıklan, Nuran, Altınışık, Zeynep
Colloids and surfaces 2019 v.575 pp. 352-362
Fourier transform infrared spectroscopy, X-ray diffraction, acrylamides, alginates, crosslinking, differential scanning calorimetry, fluorouracil, microparticles, pH, scanning electron microscopy, temperature, tissue engineering
Temperature and pH dual sensitive materials have attracted much interest in the fields of tissue engineering and drug delivery. In this study, a novel temperature and pH dual sensitive poly(N,N-diethyl acrylamide) grafted alginate (A-g-PDEA) microparticles were developed for 5-fluorouracil (5-FU) delivery. The structures of 5-FU loaded A-g-PDEA microparticles were characterized by FTIR, DSC, SEM, and XRD analyses. The effect of PDEA grafting percentage, temperature and pH on the swelling ratio and the release of 5-FU was explored. The obtained results displayed that the 5-FU release was controlled by both the temperature and pH of the medium. Furthermore, A-g-PDEA microparticles demonstrated a sustained release of 5-FU compared to free 5-FU. Moreover, the 5-FU release and swelling ratio of A-g-PDEA microparticles decreased with the increase in grafting percentage, crosslinking time and 5-FU/copolymer ratio. All the results indicated that A-g-PDEA microparticles are promising candidates for the sustained and controlled delivery of drugs.