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Eight new cytotoxic annonaceous acetogenins from the seeds of Annona squamosa

Author:
Cheng-Yao MA, Jia-Hui LU, Xiang LI, Xiao LIU, Jian-Wei CHEN
Source:
Chinese journal of natural medicines 2019 v.17 no.4 pp. 291-297
ISSN:
1875-5364
Subject:
Annona squamosa, Oriental traditional medicine, acetogenins, cell lines, cytotoxicity, multiple drug resistance, seeds, spectral analysis
Abstract:
Eight new annonaceous acetogenins, squamotin A-D (1–4), annosquatin IV-V (5 and 6), muricin O (7) and squamosten B (8), together with four known ones (9–12) were isolated from the seeds of Annona squamosa. Their structures were elucidated by chemical methods and spectral data. The inhibitory activities of compound 1–9 against three multidrug resistance cell lines were evaluated. All tested compounds showed strong cytotoxicity.
Agid:
6431013