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Anionic nanoparticle-lipid membrane interactions: the protonation of anionic ligands at the membrane surface reduces membrane disruption

Author:
Salassi, Sebastian, Canepa, Ester, Ferrando, Riccardo, Rossi, Giulia
Source:
RSC advances 2019 v.9 no.25 pp. 13992-13997
ISSN:
2046-2069
Subject:
biocompatibility, ligands, lipids, nanogold, protonation, therapeutics
Abstract:
Monolayer-protected gold nanoparticles (Au NPs) are promising biomedical tools with applications in diagnosis and therapy, thanks to their biocompatibility and versatility. Here we show how the NP surface functionalization can drive the mechanism of interaction with lipid membranes. In particular, we show that the spontaneous protonation of anionic carboxylic groups on the NP surface can make the NP-membrane interaction faster and less disruptive.
Agid:
6436130