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Four new phenolic constituents from the rhizomes of Gastrodia elata Blume

Author:
Wang, Zhi-Wei, Li, Yun, Liu, Da-Hui, Mu, Yan, Dong, Hong-Jing, Zhou, Hong-Lei, Guo, Lan-Ping, Wang, Xiao
Source:
Natural product research 2019 v.33 no.8 pp. 1140-1146
ISSN:
1478-6427
Subject:
Gastrodia elata, cell death, median effective concentration, neuroprotective effect, phenolic compounds, rhizomes
Abstract:
Four new gastrodin derivatives containing a trans-cinnamoyl unit (1–4) and nine known compounds (5–13) were isolated from the rhizomes of Gastrodia elata Blume. All these compounds were evaluated for their neuroprotective effects against 6-hydroxydopamine-induced cell death, and compounds 7 and 12 showed potent activities with EC₅₀ values of 10.5 and 10.2 μM, respectively.
Agid:
6438898