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Low-intensity resistance training with partial blood flow restriction and high-intensity resistance training induce similar changes in skeletal muscle transcriptome in elderly humans
- Vechin, Felipe C., Libardi, Cleiton A., Conceição, Miguel S., Damas, Felipe, Cavaglieri, Claudia R., Chacon-Mikahil, Mara Patricia T., Coutinho, Luiz L., Andrade, Sonia C.S., Neves Jr, Manoel T., Roschel, Hamilton, Tricoli, Valmor, Baptista, Igor L., Moriscot, Anselmo A., Ugrinowitsch, Carlos
- Applied physiology, nutrition and metabolism 2019 v.44 no.2 pp. 216-220
- blood flow, elderly, gene expression, genes, muscles, skeletal muscle, strength training, transcriptome, transcriptomics
- We aimed to investigate the mechanisms underlying muscle growth after 12 weeks of resistance training performed with blood flow restriction (RT–BFR) and high-intensity resistance training (HRT) in older individuals. Participants were allocated into the following groups: HRT, RT–BFR, or a control group. High-throughput transcriptome sequencing was performed by the Illumina HiSeq 2500 platform. HRT and RT–BFR presented similar increases in the quadriceps femoris cross-sectional area, and few genes were differently expressed between interventions. The small differences in gene expression between interventions suggest that similar mechanisms may underpin training-induced muscle growth.