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Design and synthesis of A- and D ring-modified analogues of luotonin A with reduced planarity
- Almansour, Abdulrahman I., Suresh Kumar, Raju, Arumugam, Natarajan, Bianchini, Giulia, Menéndez, J. Carlos, Al-thamili, Dhaifallah M., Periyasami, Govindasami, Altaf, Mohammad
- Tetrahedron letters 2019 v.60 no.23 pp. 1514-1517
- aldehydes, chemical reactions, chemical structure, heterocyclic compounds, imines, phenylalanine
- A small library of A- and D-ring modified luotonin-inspired heterocyclic systems have been synthesised in moderate to good yields following a six-step route that starts from phenylalanine and has the final key stage an intramolecular Povarov reaction of imines obtained from a tetrahydroquinoline-derived alkynyl aldehyde and various arylamines.