Jump to Main Content
Hear Pancreatic Cancer Stem Cells ROR
- Yao, Wantong, Maitra, Anirban
- Cell 2019 v.177 no.3 pp. 516-518
- aggression, genomics, pancreatic neoplasms, retinoic acid, stem cells, transcription factors
- In this issue of Cell, Lytle et al. (2019) integrate functional genomic approaches to identify molecular dependencies of pancreatic cancer stem cells that may be exploited therapeutically. The comprehensive analysis reveals an unexpected role for retinoic acid receptor-related orphan receptor gamma (RORγ), a T-cell-associated transcription factor, in defining the stemness and the aggressive behavior of pancreatic cancer.