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Overriding the Immune System’s Sweet Tooth: Fatty Acids Rile Up Innate Immunity

Author:
Billi, Allison C., Gudjonsson, Johann E.
Source:
Cell 2019 v.177 no.5 pp. 1088-1090
ISSN:
0092-8674
Subject:
Western diets, fatty acids, glycolysis, immune system, inflammation, innate immunity, oxidative phosphorylation, unfolded protein response
Abstract:
Mogilenko et al. dissect mechanisms by which fatty acids lead to a state of heightened innate immunity and inflammation. They reveal a metabolic adaptation to elevated fatty acids that involves a shift in the balance between glycolysis and oxidative phosphorylation and activation of the unfolded protein response, linking the high-fat Western diet to systemic inflammatory disease.
Agid:
6441460