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Overriding the Immune System’s Sweet Tooth: Fatty Acids Rile Up Innate Immunity
- Billi, Allison C., Gudjonsson, Johann E.
- Cell 2019 v.177 no.5 pp. 1088-1090
- Western diets, fatty acids, glycolysis, immune system, inflammation, innate immunity, oxidative phosphorylation, unfolded protein response
- Mogilenko et al. dissect mechanisms by which fatty acids lead to a state of heightened innate immunity and inflammation. They reveal a metabolic adaptation to elevated fatty acids that involves a shift in the balance between glycolysis and oxidative phosphorylation and activation of the unfolded protein response, linking the high-fat Western diet to systemic inflammatory disease.