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“Breathing” Hemagglutinin Reveals Cryptic Epitopes for Universal Influenza Vaccine Design
- Wu, Yan, Gao, George F.
- Cell 2019 v.177 no.5 pp. 1086-1088
- epitopes, glycoproteins, hemagglutinins, influenza, influenza vaccines
- A universal vaccine against influenza remains a critical target, and efforts have recently focused on the stem of the hemagglutinin glycoprotein. In this issue of Cell and a related Cell Host & Microbe article, three studies identify broad protective epitopes in the hemagglutinin head domain that are exposed by trimer “breathing.”