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Role of hydroxysteroid (17beta) dehydrogenase type 1 in reproductive tissues and hormone-dependent diseases

Author:
Heinosalo, Taija, Saarinen, Niina, Poutanen, Matti
Source:
Molecular and cellular endocrinology 2019 v.489 pp. 9-31
ISSN:
0303-7207
Subject:
biosynthesis, breasts, cholesterol, enzymes, estradiol, estrone, human diseases, humans, neoplasms, pathogenesis, tissues, uterus, women
Abstract:
Abnormal synthesis and metabolism of sex steroids is involved in the pathogenesis of various human diseases, such as endometriosis and cancers arising from the breast and uterus. Steroid biosynthesis is a multistep enzymatic process proceeding from cholesterol to highly active sex steroids via different intermediates. Human Hydroxysteroid (17beta) dehydrogenase 1 (HSD17B1) enzyme shows a high capacity to produce the highly active estrogen, estradiol, from a precursor hormone, estrone. However, the enzyme may also play a role in other steps of the steroid biosynthesis pathway. In this article, we have reviewed the literature on HSD17B1, and summarize the role of the enzyme in hormone-dependent diseases in women as evidenced by preclinical studies.
Agid:
6442084