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Direct production of commodity chemicals from lignocellulose using Myceliophthora thermophila
- Li, Jingen, Lin, Liangcai, Sun, Tao, Xu, Jing, Ji, Jingxiao, Liu, Qian, Tian, Chaoguang
- Metabolic engineering 2019
- Myceliophthora thermophila, batch fermentation, bioprocessing, biorefining, carbon, cellulose, corn cobs, cost effectiveness, enzymes, fuels, lignocellulose, metabolic engineering, phytomass, succinic acid, sustainable development, thermophilic fungi
- The production of fuels and chemicals from renewable plant biomass has been proposed as a feasible strategy for global sustainable development. However, the economic efficiency of biorefineries is low. Here, through metabolic engineering, Myceliophthora thermophila, a cellulolytic thermophilic fungus, was constructed into a platform that can efficiently convert lignocellulose into important bulk chemicals—four carbon 1, 4-diacids (malic and succinic acid), building blocks for biopolymers—without the need for extra hydrolytic enzymes. Titers of >200 g/L from crystalline cellulose and 110 g/L from plant biomass (corncob) were achieved during fed-batch fermentation. Our study represents a milestone in consolidated bioprocessing technology and offers a new and promising system for the cost-effective production of chemicals and fuels from biomass.