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The Upper Hand of the Otu Amyloid Fibers: Increasing Enzymatic Activity and Prolonging Lifespan
- Rabouille, Catherine
- Molecular cell 2019 v.74 no.2 pp. 225-226
- amyloid, enzyme activity, enzymes, longevity, neurodegenerative diseases
- The formation of amyloid fibers is usually associated with aging and neurodegeneration. In this issue of Molecular Cell, Ji et al. (2019) demonstrate that the deubiquitinase Otu coalesces into amyloid-like fibers to enhance its activity and ensure its optimum biological function.