PubAg

Main content area

The Upper Hand of the Otu Amyloid Fibers: Increasing Enzymatic Activity and Prolonging Lifespan

Author:
Rabouille, Catherine
Source:
Molecular cell 2019 v.74 no.2 pp. 225-226
ISSN:
1097-2765
Subject:
amyloid, enzyme activity, enzymes, longevity, neurodegenerative diseases
Abstract:
The formation of amyloid fibers is usually associated with aging and neurodegeneration. In this issue of Molecular Cell, Ji et al. (2019) demonstrate that the deubiquitinase Otu coalesces into amyloid-like fibers to enhance its activity and ensure its optimum biological function.
Agid:
6443236