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Activation of P-TEFb by RBM7: To Live or Let Die
- Le May, Nicolas, Coin, Frédéric
- Molecular cell 2019 v.74 no.2 pp. 223-224
- DNA damage, DNA-directed RNA polymerase, genes, mutagens
- In this issue of Molecular Cell, Bugai et al. (2019) unveil that a key step of the pro-survival cellular response to a genotoxic attack is the activation of P-TEFb by RBM7. This crucial step triggers RNA polymerase II release from promoter-proximal pausing and expression of DNA damage response genes.