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When Degradation Elicits the Alarm: N-Terminal Degradation of NLRP1B Unleashes Its Inflammasome Activity
- Eldeeb, Mohamed A., Fahlman, Richard P., Esmaili, Mansoore, Fon, Edward A.
- Molecular cell 2019 v.74 no.4 pp. 637-639
- immune response, inflammasomes, innate immunity, mammals
- Despite being among the first discovered mammalian innate immune sensor, NLRP1B (NLR pyrin domain-containing1B) activation and its molecular basis have remained elusive. Two recent studies have unveiled N-terminal degradation as a common mechanism for pathogen-mediated NLRP1B inflammasome activation in mammals.